Extrapolating Clinical Evidence Within Economic Evaluations


 Extrapolation is a fundamental part of many economic evaluations, though there are numerous methods extrapolating the same dataset. The method that most appropriate for decision problem contingent on several factors.
 From literature, recommendations best practices when it comes to extrapolation clinical data have been identified. These pertain validation output, use external evidence, treatment waning, proportional hazards, characterization uncertainty, reporting results, and choice model.
 Gaps remain in literature require further research regarding what minimum amount extrapolate reliably how robustly relative effects multiple comparisons.